Left ventricular ejection fraction and functional capacity: insights from cardiopulmonary exercise testing

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Cardiac rehabilitation program (CRP) is a multidisciplinary intervention tailored to improve functional fitness in different cardiovascular conditions. Patients with reduced left ventricular ejection fraction (LVEF) are commonly unrepresented hence the impact LVEF on uncertain. Purpose To evaluate changes capacity cohort patients referred CRP, according baseline LVEF. Methods Tertiary-center retrospective analysis an exercise-based phase II CRP. be enrolled had complete 12-weeks CRP and perform symptom-limiting cardiopulmonary exercise test (CPET), at beginning end program. were stratified into (LVEF < 45%) or preserved ≥ group. Four CPET parameters evaluate: peak oxygen uptake (pVO2), predicted-pVO2 (ppVO2), O2 pulse VE/VCO2 slope. Results 127 (mean age 57.8 ± 11.2 years; males 79.5%) eligible for which 86.6% following acute coronary event. included group (38.6%; mean 31% 8.1) more dyslipidemia (48.8% vs 22.8%, p = 0.013), atrial fibrillation (24.5% 7.7%, 0.008) implanted electronic devices defibrillator (30.6% 2.6%, p<0.001). Regarding parameters, lower pVO2 dif 2, 0.048), ppVO2 12.1%, p<0.001) value 0.049) higher values slope 2.9, 0.036). The Weber ARENA classifications revealed similar distribution between groups: 24.4% 27.5% entering low class (C D). Higher (III-IV) 28.5% 14.1% At program, increased by 4% 3.2% (p 0.808), about 0.7 0.5 mL/beat 0.509) reduces 1.7 0.3 0.232). As continuous variable, did not predict Weber´s 0.546) 0.393) changes. Yet, those derived greater improvement after (Δ 10.2 9.8 Δ 2.2 7.9; Conclusions All show irrespective Thus, should denied cardiac significant expected.